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Isoflavone and the heme oxygenase system in ischemic acute kidney injury in rats.

Watanabe M, de Moura Neiva LB, da Costa Santos CX, Martins Laurindo FR, de Fátima Fernandes Vattimo M

Experimental Laboratory of Animal Models (LEMA) of the School of Nursing, University of Sao Paulo, Av Enéas de Carvalho Aguiar 419, São Paulo 05403000, Brazil.

Ischemic acute kidney injury (AKI) is mediated by reactive oxygen species and inflammatory infiltration, among others. The present study was performed to evaluate the interference of isoflavone in ischemic AKI in rats and to determine whether it was mediated by the heme oxygenase (HO) system. The treatment with dry extract of isoflavone, 8 mg/kg/day, resulted in improved renal function reducing oxidative damage. The use of HO inhibitor zinc protoporphyrin (ZnPP), 50 micromol/kg, exacerbated the rates of oxidative damage, urinary peroxides, malondialdehyde (MDA), thiols and catalyse activity, whereas an HO inducer, Hemin, 1 mg/100 g body weight, demonstrated a protective effect on renal function, with a reduction in the rates of oxidative damage. Isoflavone showed a promising role in the protection against oxidative renal dysfunction and its role is probably mediated by heme-oxygenase.

Published 29 October 2007 in Food Chem Toxicol, 45(12): 2366-71.
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